L-732,138

Name: L-732,138
Brand: Tocris Bioscience
SKU: 0868
Price: 111 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0868

Citations (2)

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Key Product Details

Description:	Potent and selective NK₁ antagonist
Chemical Name:	N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	472.39

View Full Technical Details for L-732,138

Biological Activity for L-732,138

L-732,138 is a potent and highly selective competitive tachykinin NK₁ receptor antagonist (IC₅₀ = 2.3 nM).

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-732,138

M. Wt	472.39
Formula	C₂₂H₁₈F₆N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	148451-96-1
PubChem ID	44396853
InChi Key	BYYQYXVAWXAYQC-LJQANCHMSA-N
Smiles	O=C(N[C@@](CC2=CNC3=C2C=CC=C3)([H])C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-732,138

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	47.24	100
	DMSO	47.24	100

Preparing Stock Solutions for L-732,138

The following data is based on the product molecular weight 472.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.17 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for L-732,138

References are publications that support the biological activity of the product.

Kuo Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 1998 PMID: 9831906
Cascieri Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 1994 PMID: 7509807
MacLeod Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK₁ receptor. J.Med.Chem. 1994 PMID: 7513763
MacLeod N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 1993 PMID: 8393115

Citations for L-732,138 (2)

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Citations are publications that use Bio-Techne products. Selected citations for L-732,138 include:

Wan et al. (2017) Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci. 9:167
PMID: 28119567
Li et al. (2013) Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. J Neurosci. 11:294
PMID: 23345604

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Product Documents for L-732,138

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.