L-701,252

Name: L-701,252
Brand: tocris
SKU: 0705

Catalog # 0705

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	NMDA antagonist; acts at glycine site
Chemical Name:	7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone
Purity:	≥99% (HPLC)
Molecular Weight:	263.68

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Biological Activity

L-701,252 is a an antagonist at the glycine-NMDA site (IC₅₀ = 420 nM). Also a potent systemic anticonvulsant.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt	263.68
Formula	C₁₃H₁₀ClNO₃
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	151057-13-5
PubChem ID	54687453
InChi Key	MXEFWCFPCLDOOG-UHFFFAOYSA-N
Smiles	OC1=C(C(=O)C2CC2)C(=O)NC2=C1C=CC(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		50

Preparing Stock Solutions

The following data is based on the product molecular weight 263.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.58 mL	37.92 mL	75.85 mL
2.5 mM	1.52 mL	7.58 mL	15.17 mL
5 mM	0.76 mL	3.79 mL	7.58 mL
25 mM	0.15 mL	0.76 mL	1.52 mL

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References

References are publications that support the biological activity of the product.

Rowley 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 1993 PMID: 8230129
Stone Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 2000 PMID: 10740291