L-694,247

Name: L-694,247
Brand: tocris
SKU: 0781

Catalog # 0781

Citations (3)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	5-HT_1D agonist
Chemical Name:	2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Purity:	≥98% (HPLC)

View Full Technical Details for L-694,247

Complete Your Experiment

Biological Activity

Selective and extremely potent 5-HT_1D receptor agonist.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt	411.48
Formula	C₂₀H₂₁N₅O₃S
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	137403-12-4
PubChem ID	132059
InChi Key	HKXMQLISPYELRD-UHFFFAOYSA-N
Smiles	CS(=O)(=O)NC1=CC=C(CC2=NOC(=N2)C2=CC=C3NC=C(CCN)C3=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions

The following data is based on the product molecular weight 411.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.15 mL	24.30 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Beer L-694,247: a potent 5-HT_1D receptor agonist. Br.J.Pharmacol. 1993 PMID: 8298808
Buhlen Evidence for presynaptic location of inhibitory 5-HT_1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 1996 PMID: 8692282
Heald [³H]L-694,247 labels the 5-HT_1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 1994 PMID: 7851485
Street Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT_1D receptors. J.Med.Chem. 1993 PMID: 8496922

Showing 1-3 of 3 citations

Citations (3)

Citations are publications that use Bio-techne products. Selected citations for L-694,247 include:

Hampson et al. (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 50:1743
PMID: 17579833
Bhalla et al. (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol. 133:891
PMID: 11454663
Geerts et al. (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 127:1327
PMID: 10455282

L-694,247

Order Information

Shipping Information

Key Product Details

Complete Your Experiment

Complete Your Research

Biological Activity

Licensing Information

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (3)

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected