L-694,247

Name: L-694,247
Brand: tocris
SKU: 0781

Catalog # 0781

Citations (3)

Datasheet / COA / SDS

Discontinued Product

0781 has been discontinued. View all 5-HT1D Receptor Agonists products.

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Key Product Details

Description:	5-HT_1D agonist
Chemical Name:	2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Purity:	≥98% (HPLC)
Molecular Weight:	411.48

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Biological Activity

L-694,247 is a selective and extremely potent 5-HT_1D receptor agonist.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt	411.48
Formula	C₂₀H₂₁N₅O₃S
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	137403-12-4
PubChem ID	132059
InChi Key	HKXMQLISPYELRD-UHFFFAOYSA-N
Smiles	CS(=O)(=O)NC1=CC=C(CC2=NOC(=N2)C2=CC=C3NC=C(CCN)C3=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions

The following data is based on the product molecular weight 411.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.15 mL	24.30 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References

References are publications that support the biological activity of the product.

Beer L-694,247: a potent 5-HT_1D receptor agonist. Br.J.Pharmacol. 1993 PMID: 8298808
Buhlen Evidence for presynaptic location of inhibitory 5-HT_1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 1996 PMID: 8692282
Heald [³H]L-694,247 labels the 5-HT_1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 1994 PMID: 7851485
Street Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT_1D receptors. J.Med.Chem. 1993 PMID: 8496922

Citations (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-694,247 include:

Hampson et al. (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 50:1743
PMID: 17579833
Bhalla et al. (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol. 133:891
PMID: 11454663
Geerts et al. (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 127:1327
PMID: 10455282

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Product Datasheets

COA

Certificate of Analysis

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L-694,247

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Biological Activity

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References

Citations (3)

Product Datasheets

COA

Certificate of Analysis

SDS

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