KU14R

Name: KU14R
Brand: Tocris Bioscience
SKU: 1131

Tocris Bioscience a Bio-Techne Brand

Catalog # 1131

Citations (1)

COA / SDS

Discontinued Product

1131 has been discontinued. View all Imidazoline 3 (I3) Receptor Antagonists products.

Key Product Details

Description:	Antagonist of pancreatic imidazoline receptor
Chemical Name:	2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-1H-imidazole
Purity:	≥99% (HPLC)
Molecular Weight:	214.27

View Full Technical Details for KU14R

Biological Activity for KU14R

KU14R is a antagonist of the atypical imidazoline binding site (putative I₃ receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.

Technical Data for KU14R

M. Wt	214.27
Formula	C₁₃H₁₄N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	189224-48-4
PubChem ID	4302964
InChi Key	JCWVNNMJXQJVNC-UHFFFAOYSA-N
Smiles	CCC1(CC2=CC=CC=C2O1)C1=NC=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for KU14R

References are publications that support the biological activity of the product.

Mayer and Taberner Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 2002 PMID: 12409010
Chan The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent Ins secretagogue in rat and human islets of Langerhans. Br.J.Pharmacol. 1997 PMID: 9138700
Chan Clotrimazole and efaroxan stimulate Ins secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9453462

Citations for KU14R (1)

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Citations are publications that use Bio-Techne products. Selected citations for KU14R include:

Mourtada et al. (1999) Multiple effector pathways regulate the Ins secretory response to the imidazoline RX871024 in isolated rat pancreatic islets. Br J Pharmacol. 127:1279
PMID: 10455276

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Product Documents for KU14R

COA

Certificate of Analysis

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