ITH 12575

Name: ITH 12575
Brand: Tocris Bioscience
SKU: 5692

Tocris Bioscience a Bio-Techne Brand

Catalog # 5692

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Key Product Details

Description:	Mitochondrial Na⁺/Ca²⁺ exchange (mNCX) inhibitor
Chemical Name:	7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	331.86

View Full Technical Details for ITH 12575

Biological Activity for ITH 12575

ITH 12575 is a mitochondrial Na⁺/Ca²⁺ exchange (mNCX) inhibitor. Reduces Ca²⁺ efflux from the mitochondria to the cytosol in HeLa cells (EC₅₀ = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.

Compound Libraries for ITH 12575

ITH 12575 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ITH 12575

M. Wt	331.86
Formula	C₁₈H₁₈ClNOS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1802013-08-6
PubChem ID	124201848
InChi Key	RDMUJSJZBYAAEF-UHFFFAOYSA-N
Smiles	O=C1NC2=CC=C(Cl)C=C2C(C3=C(C(C)C)C=CC=C3)SC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ITH 12575

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.19	100
	ethanol	6.64	20

Preparing Stock Solutions for ITH 12575

The following data is based on the product molecular weight 331.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.13 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for ITH 12575

References are publications that support the biological activity of the product.

Martínez-Sanz Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 2015 PMID: 26192029
Moreno-Ortega Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry through CALHM1. Neuropharmacology 2015 PMID: 25908402

Citations for ITH 12575

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