IPAG

Name: IPAG
Brand: Tocris Bioscience
SKU: 0544

Catalog # 0544

Citations (2)

COA / SDS

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Key Product Details

Description:	Potent σ antagonist
Chemical Name:	1-(4-Iodophenyl)-3-(2-adamantyl)guanidine
Purity:	≥98% (HPLC)
Molecular Weight:	395.29

View Full Technical Details for IPAG

Biological Activity

IPAG is a potent σ-receptor antagonist.

Technical Data

M. Wt	395.29
Formula	C₁₇H₂₂IN₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	193527-91-2
PubChem ID	4239764
InChi Key	UUKPIWYXWLJPJF-UHFFFAOYSA-N
Smiles	IC1=CC=C(NC(=N)NC2C3CC4CC(C3)CC2C4)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	ethanol	50
	DMSO	100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.65 mL	25.30 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571
Wilson Radiosynthesis of σ receptor ligands for positron emission tomography: ¹¹C- and ¹⁸F-labelled guanidines. J.Med.Chem. 1991 PMID: 1648140

Citations for IPAG (2)

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Citations are publications that use Bio-Techne products. Selected citations for IPAG include:

Kim et al. (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 426:177
PMID: 22925888
Brimson et al. (2011) Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol. 164:772
PMID: 21486275

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