H10

Name: H10
Brand: Tocris Bioscience
SKU: 6228

Tocris Bioscience a Bio-Techne Brand

Catalog # 6228

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Description:	PARP14 inhibitor; cell-permeable
Chemical Name:	3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	557.58

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Biological Activity for H10

H10 is a PARP14 inhibitor (IC₅₀ = 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cells in vitro.

Technical Data for H10

M. Wt	557.58
Formula	C₂₄H₂₇N₇O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2084811-68-5
PubChem ID	122707115
InChi Key	MUOMSHSMJCWQFH-UHFFFAOYSA-N
Smiles	NC(C1=CC=CC(NC(CCC(NCCC2=CN(N=N2)CCNS(=O)(C3=CC(C(O)=O)=CC=C3)=O)=O)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for H10

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.88	50

Preparing Stock Solutions for H10

The following data is based on the product molecular weight 557.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.59 mL	17.93 mL	35.87 mL
2.5 mM	0.72 mL	3.59 mL	7.17 mL
5 mM	0.36 mL	1.79 mL	3.59 mL
25 mM	0.07 mL	0.36 mL	0.72 mL

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References for H10

References are publications that support the biological activity of the product.

Peng Small molecule microarray based discovery of PARP14 inhibitors. Angew.Chem.Int.Ed.Engl. 2017 PMID: 27918638

Citations for H10

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H10

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for H10

Technical Data for H10

Solubility for H10

Preparing Stock Solutions for H10

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for H10

Citations for H10

Product Documents for H10

COA

Certificate of Analysis

SDS

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