Guanabenz acetate

Name: Guanabenz acetate
Brand: Tocris Bioscience
SKU: 0885
Price: 171 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0885

Citations (5)

COA / SDS

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Key Product Details

Description:	α₂ agonist. Also I₂ selective ligand
Chemical Name:	[(2,6-Dichlorobenzylidene)amino]guanidine acetate
Purity:	≥98% (HPLC)
Molecular Weight:	291.14

View Full Technical Details for Guanabenz acetate

Biological Activity for Guanabenz acetate

Guanabenz acetate is a α₂-adrenergic agonist and IGRS (imidazoline I₂ binding site) selective ligand.

Technical Data for Guanabenz acetate

M. Wt	291.14
Formula	C₈H₈Cl₂N₄.CH₃CO₂H
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	23256-50-0
PubChem ID	5702062
InChi Key	MCSPBPXATWBACD-GAYQJXMFSA-N
Smiles	CC(O)=O.ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Guanabenz acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.84	75

Preparing Stock Solutions for Guanabenz acetate

The following data is based on the product molecular weight 291.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.58 mL	22.90 mL	45.80 mL
3.75 mM	0.92 mL	4.58 mL	9.16 mL
7.5 mM	0.46 mL	2.29 mL	4.58 mL
37.5 mM	0.09 mL	0.46 mL	0.92 mL

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References for Guanabenz acetate

References are publications that support the biological activity of the product.

Evans and Anderson Renal effects of infusion of rilmenidine and guan. in conscious dogs: contribution of peripheral and central nervous system α₂-adrenoceptors. Br.J.Pharmacol. 1995 PMID: 8564219
Michel and Insel Are there multiple imidazoline binding sites? Trends Pharmacol.Sci. 1989 PMID: 2690423
Holmes Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 1983 PMID: 6352237

Citations for Guanabenz acetate (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Guanabenz acetate include:

Nevin et al. (2017) Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes. Am J Hum Genet. 100:617
PMID: 28366443
Hamamura et al. (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Proc Natl Acad Sci U S A. 4:84
PMID: 25977571
Wan et al. (2014) Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS One. 9:e105699
PMID: 25157407
Ye et al. (2013) Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. J Korean Med Sci. 110:141
PMID: 23248313
Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Bone Joint Res. 24:7745
PMID: 15342742

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Showing 1 - 5 of 5 citations Showing All

Product Documents for Guanabenz acetate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.