GRK2i

Name: GRK2i
Brand: Tocris Bioscience
SKU: 3594

Tocris Bioscience a Bio-Techne Brand

Catalog # 3594

Citations (2)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	GRK2 inhibitory polypeptide; G_β/γ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	3484.08

View Full Technical Details for GRK2i

Biological Activity for GRK2i

GRK2i is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.

Technical Data for GRK2i

M. Wt	3484.08
Formula	C₁₅₃H₂₅₆N₅₀O₄₁S
Single Letter Sequence	WKKELRDAYREAQQLVQRVPKMKNKPRS
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	148505-03-7
PubChem ID	90488863
InChi Key	QYWJBYYWQATYFS-ICUWLHSYSA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GRK2i

Solubility

Soluble to 2mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for GRK2i

References are publications that support the biological activity of the product.

Dang Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 2009 PMID: 19279269
Macrez A βγ dimer derived from G₁₃ transduces the angiotensin AT₁ receptor signal to stimulation of Ca²⁺ channels in rat portal vein myocytes. J.Biol.Chem. 1997 PMID: 9287322
Koch Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G_βγ-mediated signaling. J.Biol.Chem. 1994 PMID: 8119963

Citations for GRK2i (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for GRK2i include:

Stott et al. (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Apoptosis. 112:6497
PMID: 25941381
Sierra-Fonseca et al. (2014) Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci. 15:132
PMID: 25552352

There are no citations that match your criteria.