GR 135531

Name: GR 135531
Brand: tocris
SKU: 0896

Catalog # 0896

Citations (5)

Datasheet / COA / SDS

Discontinued Product

0896 has been discontinued. View all Melatonin (MT) Receptor Ligands products.

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Bio-Techne Corporation

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$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	High affinity melatonin MT₃ ligand
Alternative Names:	5-MCA-NAT
Chemical Name:	5-Methoxycarbonylamino-N-acetyltryptamine
Purity:	≥97% (HPLC)
Molecular Weight:	275.31

View Full Technical Details for GR 135531

Technical Data
Citations (5) / Reviews

Biological Activity

Binds with high affinity to MT₃ melatonin sites in hamster brain, and low affinity (and no efficacy) at MT₁ and MT₂ melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.

Technical Data

M. Wt	275.31
Formula	C₁₄H₁₇N₃O₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	190277-13-5
PubChem ID	4284525
InChi Key	MPZVHKLZCUEJFO-UHFFFAOYSA-N
Smiles	COC(=O)NC1=CC=C2NC=C(CCNC(C)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol		100

Preparing Stock Solutions

The following data is based on the product molecular weight 275.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.63 mL	18.16 mL	36.32 mL
5 mM	0.73 mL	3.63 mL	7.26 mL
10 mM	0.36 mL	1.82 mL	3.63 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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References

References are publications that support the biological activity of the product.

Dubocovich Melatonin receptors: are there multiple subtypes? TiPS 1995 PMID: 7762083
Lucchelli Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT₄ and melatonin receptors. Br.J.Pharmacol. 1997 PMID: 9283717

Citations (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for GR 135531 include:

Loma et al. (2015) Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability. J Neurosci. 172:1045
PMID: 25297531
Crooke et al. (2013) Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma. J Pharmacol Exp Ther. 346:138
PMID: 23591996
Kojima et al. (2011) Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol. 162:1179
PMID: 21091649
Tunstall et al. (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. Br J Pharmacol. 336:127
PMID: 20959363
Sjöblom et al. (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther. 108:625
PMID: 11518737

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Showing 1 - 5 of 5 citations Showing All

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

GR 135531

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Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (5)

Product Datasheets

COA

Certificate of Analysis

SDS

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