Glimepiride

Name: Glimepiride
Brand: Tocris Bioscience
SKU: 2396
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 2396

(1)

COA / SDS

Discontinued Product

2396 has been discontinued. View all Inward Rectifier Potassium Channel Blockers products.

Key Product Details

Description:	K_ir6 (K_ATP) channel blocker
Alternative Names:	Amaryl, Glimperide
Chemical Name:	3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	490.62

View Full Technical Details for Glimepiride

Biological Activity for Glimepiride

Glimepiride is a potent K_ir6 (K_ATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K_ir6 channels with an IC₅₀ of 6.8 nM.

Technical Data for Glimepiride

M. Wt	490.62
Formula	C₂₄H₃₄N₄O₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	93479-97-1
PubChem ID	3476
InChi Key	WIGIZIANZCJQQY-UHFFFAOYSA-N
Smiles	O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Glimepiride

References are publications that support the biological activity of the product.

Lawrence Effect of metabolic inhibition on glimep. block of native and cloned cardiac sacrolemmal K_ATP channels. Br.J.Pharmacol. 2002 PMID: 12086984

Citations for Glimepiride

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Glimepiride was used to evaluate the role of BK channel modulation on insulin secretion

Name: Anonymous

Species: Human

Assay Type: In Vitro

In pancreatic beta cells,ATP dependent potassium channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes.To understand the role of BK channels on insulin secretion,Glimepiride was used.

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Product Documents for Glimepiride

COA

Certificate of Analysis

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