GBR 13069 dihydrochloride

Name: GBR 13069 dihydrochloride
Brand: Tocris Bioscience
SKU: 0420

Tocris Bioscience a Bio-Techne Brand

Catalog # 0420

COA / SDS

Discontinued Product

0420 has been discontinued. View all Dopamine Transporter Inhibitors products.

Key Product Details

Description:	Potent dopamine uptake inhibitor
Chemical Name:	(1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Molecular Weight:	521.48

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Biological Activity for GBR 13069 dihydrochloride

GBR 13069 dihydrochloride is a potent inhibitor of dopamine uptake (IC₅₀ = 40 nM). Centrally active following systemic administration in vivo.

Technical Data for GBR 13069 dihydrochloride

M. Wt	521.48
Formula	C₂₈H₃₀F₂N₂O.2HCl
Storage	Desiccate at RT
CAS Number	67469-45-8
PubChem ID	24978531
InChi Key	ZBSZWEYIIGLGSX-RDRKJGRWSA-N
Smiles	FC(C=C2)=CC=C2C(OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C1=CC=C(F)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GBR 13069 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		5

Preparing Stock Solutions for GBR 13069 dihydrochloride

The following data is based on the product molecular weight 521.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	38.35 mL	191.76 mL	383.52 mL
0.25 mM	7.67 mL	38.35 mL	76.70 mL
0.5 mM	3.84 mL	19.18 mL	38.35 mL
2.5 mM	0.77 mL	3.84 mL	7.67 mL

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References for GBR 13069 dihydrochloride

References are publications that support the biological activity of the product.

Mayer Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 1986 PMID: 3489072
Van der Zee and Hespe Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and DA receptors. Neuropharmacology 1985 PMID: 4094653
Heikkila Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of DA uptake. Eur.J.Pharmacol. 1984 PMID: 6237922

Citations for GBR 13069 dihydrochloride

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