FLI 06

Tocris Bioscience a Bio-Techne Brand

Catalog # 5172

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Key Product Details

Description:	Inhibitor of Notch signaling; disrupts Notch trafficking and processing
Chemical Name:	Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Purity:	≥99% (HPLC)
Molecular Weight:	438.52

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Biological Activity for FLI 06

FLI 06 is an inhibitor of Notch signaling (EC₅₀ = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.

Technical Data for FLI 06

M. Wt	438.52
Formula	C₂₅H₃₀N₂O₅
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	313967-18-9
PubChem ID	3103157
InChi Key	SWWVFYHSSOWZMF-UHFFFAOYSA-N
Smiles	O=C(OC3CCCCC3)C1=C(C)NC(CC(C)(C)CC4=O)=C4C1C2=CC=C([N+]([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FLI 06

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.85	100
	ethanol	8.77	20

Preparing Stock Solutions for FLI 06

The following data is based on the product molecular weight 438.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.80 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for FLI 06

References are publications that support the biological activity of the product.

Krämer Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 2013 PMID: 24077179

Citations for FLI 06

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FLI 06

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for FLI 06

Technical Data for FLI 06

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Preparing Stock Solutions for FLI 06

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Reconstitution Calculator

References for FLI 06

Citations for FLI 06

Product Documents for FLI 06

COA

Certificate of Analysis

SDS

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