Fenoprofen calcium

Name: Fenoprofen calcium
Brand: Tocris Bioscience
SKU: 6926

Tocris Bioscience a Bio-Techne Brand

Catalog # 6926

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Key Product Details

Description:	Positive allosteric modulator of MC₃ receptors; exhibits biased signaling
Chemical Name:	α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt
Purity:	≥98% (HPLC)
Molecular Weight:	261.31

View Full Technical Details for Fenoprofen calcium

Biological Activity for Fenoprofen calcium

Fenoprofen calcium is a melanocortin 3 (MC₃) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC₅₀ = 8.69); decreases the EC₅₀ of α-MSH at MC₃R. Stimulates ERK1/2 activation at MC₃_-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC₃R, 1 μM for MC₄R, and 3 μM for MC₅R. Exhibits biased signaling at MC₃_-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.

Technical Data for Fenoprofen calcium

M. Wt	261.31
Formula	C₁₅H₁₃O₃.0.5Ca
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	34597-40-5
PubChem ID	64746
InChi Key	VHUXSAWXWSTUOD-UHFFFAOYSA-L
Smiles	CC(C1=CC=CC(OC2=CC=CC=C2)=C1)C([O-])=O.CC(C3=CC=CC(OC4=CC=CC=C4)=C3)C([O-])=O.[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fenoprofen calcium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.13	100
	ethanol	13.07	50

Preparing Stock Solutions for Fenoprofen calcium

The following data is based on the product molecular weight 261.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.83 mL	19.13 mL	38.27 mL
5 mM	0.77 mL	3.83 mL	7.65 mL
10 mM	0.38 mL	1.91 mL	3.83 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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References for Fenoprofen calcium

References are publications that support the biological activity of the product.

Yuan Fenoprofen-an old drug rediscovered as a biased allosteric enhancer for melanocortin receptors. ACS Chem.Neurosci. 2019 PMID: 30168706
Montero-Melendez Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 Cell Mol.Life Sci. 2017 PMID: 27853832

Citations for Fenoprofen calcium

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