Felbamate

Name: Felbamate
Brand: tocris
SKU: 0869
Rating: 5 (1 reviews)

Catalog # 0869

(1)

Datasheet / COA / SDS

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Key Product Details

Description:	NMDA antagonist; acts glycine site
Chemical Name:	2-Phenyl-1,3-propanedioldicarbamate
Purity:	≥99% (HPLC)

View Full Technical Details for Felbamate

Technical Data
Citations / Reviews (1)

Biological Activity

Anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.

Compound Libraries

Felbamate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	238.24
Formula	C₁₁H₁₄N₂O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	25451-15-4
PubChem ID	3331
InChi Key	WKGXYQFOCVYPAC-UHFFFAOYSA-N
Smiles	NC(=O)OCC(COC(N)=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.82	100
	ethanol	23.82	100

Preparing Stock Solutions

The following data is based on the product molecular weight 238.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.20 mL	20.99 mL	41.97 mL
5 mM	0.84 mL	4.20 mL	8.39 mL
10 mM	0.42 mL	2.10 mL	4.20 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Coffin Selective antagonism of the anticonvulsant effects of felb. by glycine. Eur.J.Pharmacol. 1994 PMID: 8050461
De Sarro Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felb. in DBA/2 mice. Eur.J.Pharmacol. 1994 PMID: 7529182
Serra Felbamate antagonises isoniazid- and FG7142-induced reduction of GABA_A receptor function in the mouse brain. Eur.J.Pharmacol. 1994 PMID: 7875235
Upton Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 1994 PMID: 7886818

Citations

Currently there are no citations for Felbamate.

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Block of NMDA receptor glycine site

Name: Sergiy Sylantyev | 15th Oct 2020

Species: Human

Cell Line/Tissue: Stem cell - derived neurons

Felbamate was in use as an NMDA receptor antagonist affecting glycine site, to study (possible) competition of dopamine for this site. Application of felbamate and dopamine mixtures in different ratios resulted in a significant decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in DMSO. Illustration: the effect of 75% dopamine EC50 + 25% Felbamate EC50 on NMDA receptor single-channel openings (top trace); then 50%/50% and 25%/75% ratios.

Reference