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Felbamate

NMDA Receptor Antagonists Small Molecule

Key Product Details

Description: NMDA antagonist; acts glycine site
Chemical Name: 2-Phenyl-1,3-propanedioldicarbamate
Purity: ≥99% (HPLC)

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  • Block of NMDA receptor glycine site
    Name: Sergiy Sylantyev | 15th Oct 2020
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    Felbamate was in use as an NMDA receptor antagonist affecting glycine site, to study (possible) competition of dopamine for this site. Application of felbamate and dopamine mixtures in different ratios resulted in a significant decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in DMSO. Illustration: the effect of 75% dopamine EC50 + 25% Felbamate EC50 on NMDA receptor single-channel openings (top trace); then 50%/50% and 25%/75% ratios.
    Block of NMDA receptor glycine site Serum 0869

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