Etazolate hydrochloride

Name: Etazolate hydrochloride
Brand: tocris
SKU: 0438

Catalog # 0438

Datasheet / COA / SDS

Discontinued Product

0438 has been discontinued. View all Phosphodiesterase Inhibitors products.

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	PDE4 inhibitor
Chemical Name:	1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	325.8

View Full Technical Details for Etazolate hydrochloride

Technical Data
Citations / Reviews

Biological Activity

Etazolate hydrochloride is a phosphodiesterase inhibitor, selective for PDE4 (IC₅₀ = 2.0 μM).

Technical Data

M. Wt	325.8
Formula	C₁₄H₁₉N₅O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	35838-58-5
PubChem ID	37274
InChi Key	GQJUGJHJUZSJLZ-UHFFFAOYSA-N
Smiles	CCN2C1=NC=C(C(OCC)=O)C(NN=C(C)C)=C1C=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		50
	DMSO	32.58	100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.35 mL	30.69 mL
5 mM	0.61 mL	3.07 mL	6.14 mL
10 mM	0.31 mL	1.53 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Ahluwalia and Nicholson Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 1991 PMID: 1848733
Chesin 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 1972 PMID: 4345859
Rhoads Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 1982 PMID: 6177320