Etazolate hydrochloride

Name: Etazolate hydrochloride
Brand: Tocris Bioscience
SKU: 0438

Catalog # 0438

COA / SDS

Discontinued Product

0438 has been discontinued. View all Phosphodiesterase Inhibitors products.

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	PDE4 inhibitor
Chemical Name:	1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	325.8

View Full Technical Details for Etazolate hydrochloride

Biological Activity

Etazolate hydrochloride is a phosphodiesterase inhibitor, selective for PDE4 (IC₅₀ = 2.0 μM).

Technical Data

M. Wt	325.8
Formula	C₁₄H₁₉N₅O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	35838-58-5
PubChem ID	37274
InChi Key	GQJUGJHJUZSJLZ-UHFFFAOYSA-N
Smiles	CCN2C1=NC=C(C(OCC)=O)C(NN=C(C)C)=C1C=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		50
	DMSO	32.58	100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.35 mL	30.69 mL
5 mM	0.61 mL	3.07 mL	6.14 mL
10 mM	0.31 mL	1.53 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Ahluwalia and Nicholson Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 1991 PMID: 1848733
Rhoads Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 1982 PMID: 6177320
Chesin 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 1972 PMID: 4345859

Citations for Etazolate hydrochloride

View all citations for the Small Molecules and Peptides platform.
Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.