Endomorphin-2

Name: Endomorphin-2
Brand: Tocris Bioscience
SKU: 1056

Catalog # 1056

Citations (1)

COA / SDS

Discontinued Product

1056 has been discontinued. View all mu Opioid Receptor Agonists products.

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Key Product Details

Description:	Potent and selective μ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	571.65

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Biological Activity

Endomorphin-2 is a endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors (with K_i values of 0.69, 9233 and 5240 nM for μ, δ and κ respectively).

Technical Data

M. Wt	571.65
Formula	C₃₂H₃₇N₅O₅
Single Letter Sequence	YPFF (Modifications: Phe-3 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	141801-26-5
PubChem ID	5311081
InChi Key	XIJHWXXXIMEHKW-LJWNLINESA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 0.4mg/ml in water

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References

References are publications that support the biological activity of the product.

Harrison Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 1998 PMID: 9622031
Goldberg Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9694962
Chapman Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 1997 PMID: 9422796
Zadina A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997 PMID: 9087409

Citations for Endomorphin-2 (1)

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Citations are publications that use Bio-Techne products. Selected citations for Endomorphin-2 include:

Garzón et al. (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology. 29:1091
PMID: 14997173

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