EBPC

Name: EBPC
Brand: tocris
SKU: 0518

Catalog # 0518

Citations (2)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	Aldose reductase inhibitor
Chemical Name:	Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Purity:	≥99% (HPLC)

View Full Technical Details for EBPC

Technical Data
Citations (2) / Reviews

Biological Activity

Potent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt	261.28
Formula	C₁₄H₁₅NO₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	4450-98-0
PubChem ID	54677973
InChi Key	IGYRPDIWSYGHMY-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C(O)C(=O)N(CC2=CC=CC=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	50

Preparing Stock Solutions

The following data is based on the product molecular weight 261.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.83 mL	19.14 mL	38.27 mL
5 mM	0.77 mL	3.83 mL	7.65 mL
10 mM	0.38 mL	1.91 mL	3.83 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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References

References are publications that support the biological activity of the product.

Kyoung Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 2002 PMID: 12394272
Mylari A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 1991 PMID: 1900532

Showing 1-2 of 2 citations

Citations (2)

Citations are publications that use Bio-techne products. Selected citations for EBPC include:

Seo et al. (2014) Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Pharmacol Res Perspect. 90:99
PMID: 24695626
Bresson et al. (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol. 3:98
PMID: 22654757

EBPC

Order Information

Shipping Information

Key Product Details

Biological Activity

Licensing Information

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (2)

Product Datasheets

COA

Certificate of Analysis

SDS

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