DTG specifically protects sigma-1 and sigma-2 receptors binding sites.
Name: Timur Mavlyutov
| 6th Jan 2018
Assay Type: In Vitro
Cell Line/Tissue: PC12
Photolabeling experiment by Iodoazidofenpropimorph labels multiple receptors, which can be later seen on auto radiogram. Sigma-1 (26kDa) and Sigma-2 (18kDa) receptors were also labeled. To be sure that these two bands are true Sigma-1 and Sigma-2 receptors, photolabeling experiment was performed in the presence of DTG (second lane). Both Sigma-1 and Sigma-2 receptors were selectively protected.