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General Sigma Receptor Ligands Small Molecule

Key Product Details

Description: High affinity ligand (σ1 = σ2)
Chemical Name: 1,3-Di-(2-tolyl)guanidine
Molecular Weight: 239.32

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  • DTG specifically protects sigma-1 and sigma-2 receptors binding sites.
    Name: Timur Mavlyutov
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: PC12
    Photolabeling experiment by Iodoazidofenpropimorph labels multiple receptors, which can be later seen on auto radiogram. Sigma-1 (26kDa) and Sigma-2 (18kDa) receptors were also labeled. To be sure that these two bands are true Sigma-1 and Sigma-2 receptors, photolabeling experiment was performed in the presence of DTG (second lane). Both Sigma-1 and Sigma-2 receptors were selectively protected.
    DTG Serum 0841

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