(±)-Bisoprolol hemifumarate

Name: (±)-Bisoprolol hemifumarate
Brand: tocris
SKU: 0914

Catalog # 0914

Citations (3)

Datasheet / COA / SDS

Discontinued Product

0914 has been discontinued. View all Adrenergic beta-1 Receptor Antagonists products.

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Key Product Details

Description:	β₁ antagonist
Chemical Name:	(±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate
Purity:	≥98%
Molecular Weight:	383.48

View Full Technical Details for (±)-Bisoprolol hemifumarate

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Biological Activity

A selective β₁-adrenergic antagonist. Has a K_d of 2-3 nM at the β₁ receptor and a β₁/β₂ selectivity of approximately 100-fold.

Technical Data

M. Wt	383.48
Formula	C₁₈H₃₁NO₄.½C₄H₄O₄
Storage	Store at RT
Purity	≥98%
CAS Number	104344-23-2
PubChem ID	5281064
InChi Key	VMDFASMUILANOL-WXXKFALUSA-N
Smiles	OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.17	50

Preparing Stock Solutions

The following data is based on the product molecular weight 383.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.22 mL	26.08 mL	52.15 mL
2.5 mM	1.04 mL	5.22 mL	10.43 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
25 mM	0.10 mL	0.52 mL	1.04 mL

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References

References are publications that support the biological activity of the product.

Heible α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 1995 PMID: 7658428
Kaumann and Lemoine Direct labelling of myocardial β₁-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 1985 PMID: 2866449
Klockow Studies on the receptor profile of bisop. Arzneimittelforschung 1986 PMID: 2870719

Citations (3)

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Citations are publications that use Bio-Techne products. Selected citations for (±)-Bisoprolol hemifumarate include:

Littmann et al. (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. PLoS One. 355:183
PMID: 26306764
Baker et al. (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J. 25:4486
PMID: 21865315
Kam et al. (2005) Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats. Br J Pharmacol. 144:972
PMID: 15685204

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Product Datasheets

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Certificate of Analysis

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SDS

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(±)-Bisoprolol hemifumarate

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References

Citations (3)

Product Datasheets

COA

Certificate of Analysis

SDS

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