Dihydroergotamine mesylate

Name: Dihydroergotamine mesylate
Brand: tocris
SKU: 0475

Catalog # 0475

Datasheet / COA / SDS

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Key Product Details

Description:	α partial agonist; also D₂-like partial agonist and 5-HT antagonist
Chemical Name:	9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	679.79

View Full Technical Details for Dihydroergotamine mesylate

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Biological Activity

Partial α-adrenergic agonist. Partial D₂ dopaminergic receptor agonist. Competitive 5-HT antagonist.

Compound Libraries

Dihydroergotamine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	679.79
Formula	C₃₃H₃₇N₅O₅.CH₃SO₃H
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	6190-39-2
PubChem ID	71171
InChi Key	ADYPXRFPBQGGAH-UMYZUSPBSA-N
Smiles	CS(=O)(O)=O.[H][C@]4([C@@]([H])3C[C@@H]([C@@](N[C@@]5(C)C(N([C@@]([H])(CC8=CC=CC=C8)C(N7[C@]([H])6CCC7)=O)[C@@]6(O)O5)=O)=O)CN4C)CC1=CNC2=C1C3=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	67.97	100

Preparing Stock Solutions

The following data is based on the product molecular weight 679.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.47 mL	7.36 mL	14.71 mL
5 mM	0.29 mL	1.47 mL	2.94 mL
10 mM	0.15 mL	0.74 mL	1.47 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

de Boer Carotid vascular effects of ergot. and dihydroergot. in the pig: no exclusive mediation via 5-HT₁-like receptors. Br.J.Pharmacol. 1991 PMID: 1664762
Doggrell Further analysis of the inhibitory effects of dihydroergotamine, cyprohept. and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. J.Auton.Pharmacol. 1992 PMID: 1512277
Lesage Agonistic properties of alniditan, sumatr. and dihydroergot. on human 5-HT_1B and 5-HT_1D receptors expressed in various mammalian cell lines. Br.J.Pharmacol. 1998 PMID: 9605573
Villalon Effects of S9977 and dihydroergot. in an animal experimental model for migraine. Pharmacol.Res. 1992 PMID: 1635891

Citations

Currently there are no citations for Dihydroergotamine mesylate.

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Dihydroergotamine mesylate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov