D-erythro-Sphingosine (synthetic)

Name: D- erythro -Sphingosine (synthetic)
Brand: Tocris Bioscience
SKU: 0633

Catalog # 0633

COA / SDS

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Bio-Techne Corporation

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Key Product Details

Description:	Protein kinase C inhibitor
Chemical Name:	trans-D-erythro-2-Amino-4-octadecene-1,3-diol
Molecular Weight:	299.5

View Full Technical Details for D-erythro-Sphingosine (synthetic)

Biological Activity

D-erythro-Sphingosine (synthetic) is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.

Technical Data

M. Wt	299.5
Formula	C₁₈H₃₇NO₂
Storage	Store at -20°C
CAS Number	123-78-4
PubChem ID	5280335
InChi Key	WWUZIQQURGPMPG-KRWOKUGFSA-N
Smiles	N[C@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	5
	ethanol	50

Preparing Stock Solutions

The following data is based on the product molecular weight 299.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.68 mL	33.39 mL	66.78 mL
2.5 mM	1.34 mL	6.68 mL	13.36 mL
5 mM	0.67 mL	3.34 mL	6.68 mL
25 mM	0.13 mL	0.67 mL	1.34 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Grossman Sphingosine inhibition and promotion of histamine release from isolated rat mast cells. Agents Actions 1990 PMID: 1707581
Merrill Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 1989 PMID: 2742830

Citations for D-erythro-Sphingosine (synthetic)

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