CL 218872

Name: CL 218872
Brand: Tocris Bioscience
SKU: 1709

Tocris Bioscience, part of Bio-Techne | Catalog # 1709

Citations (7)

COA / SDS

Benzodiazepine agonist

Discontinued Product

1709 has been discontinued. View all GABA-A Receptor Benzodiazepines products.

Key Product Details

Description:	Benzodiazepine agonist
Chemical Name:	3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Purity:	≥98% (HPLC)
Molecular Weight:	278.24

View Full Technical Details for CL 218872

Technical Data
Citations

Biological Activity for CL 218872

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABA_A receptors (K_i values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data for CL 218872

M. Wt	278.24
Formula	C₁₃H₉F₃N₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	66548-69-4
PubChem ID	107950
InChi Key	GUOQUXNJZHGPQF-UHFFFAOYSA-N
Smiles	CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CL 218872

References are publications that support the biological activity of the product.

Sieghart Structure and pharmacology of γ-aminobutyric acid_A receptor subtypes. Pharmacol.Rev. 1995 PMID: 7568326
Squires Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 1979 PMID: 40257
Lippa Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 1979 PMID: 40258

CL 218872

Tocris Bioscience, part of Bio-Techne | Catalog # 1709

Key Product Details

Biological Activity for CL 218872

Technical Data for CL 218872

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CL 218872

Product Documents for CL 218872

COA

Certificate of Analysis

SDS

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