Chlormethiazole hydrochloride

Name: Chlormethiazole hydrochloride
Brand: Tocris Bioscience
SKU: 0881

Tocris Bioscience a Bio-Techne Brand

Catalog # 0881

COA / SDS

Discontinued Product

0881 has been discontinued. View all GABA-A Receptor Modulators products.

Key Product Details

Description:	Potentiates GABA_A receptor function
Chemical Name:	5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	198.11

View Full Technical Details for Chlormethiazole hydrochloride

Biological Activity for Chlormethiazole hydrochloride

Chlormethiazole hydrochloride is a sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').

Technical Data for Chlormethiazole hydrochloride

M. Wt	198.11
Formula	C₆H₈ClNS.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	6001-74-7
PubChem ID	19035073
InChi Key	OFXYKSLKNMTBHK-UHFFFAOYSA-N
Smiles	ClCCC1=C(C)N=CS1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chlormethiazole hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.81	100

Preparing Stock Solutions for Chlormethiazole hydrochloride

The following data is based on the product molecular weight 198.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.05 mL	25.24 mL	50.48 mL
5 mM	1.01 mL	5.05 mL	10.10 mL
10 mM	0.50 mL	2.52 mL	5.05 mL
50 mM	0.10 mL	0.50 mL	1.01 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Chlormethiazole hydrochloride

References are publications that support the biological activity of the product.

Cross The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 1995 PMID: 7599932
Hewitt and Green Chloromethiazole, dizocilpine and halope. prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 1994 PMID: 7539115

Citations for Chlormethiazole hydrochloride

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.