Chlormethiazole hydrochloride

Name: Chlormethiazole hydrochloride
Brand: tocris
SKU: 0881

Catalog # 0881

Datasheet / COA / SDS

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Key Product Details

Description:	Potentiates GABA_A receptor function
Chemical Name:	5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Purity:	≥99% (HPLC)

View Full Technical Details for Chlormethiazole hydrochloride

Biological Activity

Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').

Technical Data

M. Wt	198.11
Formula	C₆H₈ClNS.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	6001-74-7
PubChem ID	19035073
InChi Key	OFXYKSLKNMTBHK-UHFFFAOYSA-N
Smiles	ClCCC1=C(C)N=CS1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.81	100

Preparing Stock Solutions

The following data is based on the product molecular weight 198.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.05 mL	25.24 mL	50.48 mL
5 mM	1.01 mL	5.05 mL	10.10 mL
10 mM	0.50 mL	2.52 mL	5.05 mL
50 mM	0.10 mL	0.50 mL	1.01 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Cross The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 1995 PMID: 7599932
Hewitt and Green Chloromethiazole, dizocilpine and halope. prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 1994 PMID: 7539115