Chlorisondamine diiodide

Name: Chlorisondamine diiodide
Brand: tocris
SKU: 1001

Catalog # 1001

Citations (4)

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Key Product Details

Description:	nAChR antagonist; slow offset
Alternative Names:	3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide
Chemical Name:	4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide
Purity:	≥99% (HPLC)
Molecular Weight:	611.95

View Full Technical Details for Chlorisondamine diiodide

Biological Activity

An exceptionally long lasting nicotinic antagonist (IC₅₀ ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

Technical Data

M. Wt	611.95
Formula	C₁₄H₂₀Cl₄I₂N₂
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	96750-66-2
PubChem ID	16078959
InChi Key	FPNVAOZHQUJJJQ-UHFFFAOYSA-L
Smiles	[I-].[I-].C[N+](C)(C)CC[N+]1(C)CC2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	6.12	10

Preparing Stock Solutions

The following data is based on the product molecular weight 611.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.34 mL	81.71 mL	163.41 mL
0.5 mM	3.27 mL	16.34 mL	32.68 mL
1 mM	1.63 mL	8.17 mL	16.34 mL
5 mM	0.33 mL	1.63 mL	3.27 mL

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References

References are publications that support the biological activity of the product.

Clarke The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 1994 PMID: 7911713
El-Bizri and Clarke Blockade of nicotinic receptor-mediated release of DA from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 1994 PMID: 8004384
El-Bizri and Clarke Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 1994 PMID: 7858886

Citations (4)

Showing 1- 4 of 4 citations Showing All

Citations are publications that use Bio-Techne products. Selected citations for Chlorisondamine diiodide include:

Sabharwal et al. (2015) Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. J Exp Med. 100:776
PMID: 25921929
Sabharwal et al. (2014) Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. J Cereb Blood Flow Metab. 127:101
PMID: 24502705
Bucci et al. (2013) Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function. Br J Pharmacol. 168:411
PMID: 22957757
Luyer et al. (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. Clin Sci (Lond). 202:1023
PMID: 16216887

Chlorisondamine diiodide

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References

Citations (4)

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