CFM-2

Catalog # 1082

Citations (4)

COA / SDS

Discontinued Product

1082 has been discontinued. View all AMPA Receptor Antagonists products.

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Bio-Techne Corporation

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tel: (612) 379-2956

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$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	Non-competitive AMPA antagonist
Chemical Name:	1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	311.34

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Biological Activity

CFM-2 is a novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.

Technical Data

M. Wt	311.34
Formula	C₁₇H₁₇N₃O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	178616-26-7
PubChem ID	4377504
InChi Key	MJKADKZSYQWGLL-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1OC)C(=NNC(=O)C2)C1=CC=C(N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.13	100

Preparing Stock Solutions

The following data is based on the product molecular weight 311.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.06 mL	32.12 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.61 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References

References are publications that support the biological activity of the product.

De Sarro Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol.Biochem.Behav. 1999 PMID: 10462191
De Sarro Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur.J.Pharmacol. 1999 PMID: 10193651
Chimirri 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. J.Med.Chem. 1997 PMID: 9111300

Citations for CFM-2 (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CFM-2 include:

Park et al. (2016) Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci. 57:508
PMID: 26868754
Nygaard et al. (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Proc Natl Acad Sci U S A. 1:82
PMID: 25593989
Park et al. (2009) Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 4:67
PMID: 19116032
Rzeski et al. (2001) Glutamate antagonists limit tumor growth. J Pharmacol Exp Ther. 98:6372
PMID: 11331750

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