CCF 642

Name: CCF 642
Brand: Tocris Bioscience
SKU: 6063

Tocris Bioscience a Bio-Techne Brand

Catalog # 6063

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Key Product Details

Description:	Protein disulfide isomerase (PDI) inhibitor
Chemical Name:	3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Purity:	≥98% (HPLC)
Molecular Weight:	378.45

View Full Technical Details for CCF 642

Biological Activity for CCF 642

CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.

Technical Data for CCF 642

M. Wt	378.45
Formula	C₁₅H₁₀N₂O₄S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	346640-08-2
PubChem ID	1820764
InChi Key	SPYIETQLOVDJCF-XYOKQWHBSA-N
Smiles	COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCF 642

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.57	20

Preparing Stock Solutions for CCF 642

The following data is based on the product molecular weight 378.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.21 mL	66.06 mL	132.12 mL
1 mM	2.64 mL	13.21 mL	26.42 mL
2 mM	1.32 mL	6.61 mL	13.21 mL
10 mM	0.26 mL	1.32 mL	2.64 mL

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References for CCF 642

References are publications that support the biological activity of the product.

Vatolin Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 2016 PMID: 27197150

Citations for CCF 642

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