Castanospermine

Name: Castanospermine
Brand: Tocris Bioscience
SKU: 0759

Tocris Bioscience a Bio-Techne Brand

Catalog # 0759

Citations (1)

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Key Product Details

Description:	Glucosidases α and β inhibitor
Chemical Name:	[1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Molecular Weight:	189.21

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Biological Activity for Castanospermine

Castanospermine is a potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Technical Data for Castanospermine

M. Wt	189.21
Formula	C₈H₁₅NO₄
Storage	Store at RT
CAS Number	79831-76-8
PubChem ID	54445
InChi Key	JDVVGAQPNNXQDW-TVNFTVLESA-N
Smiles	[H][C@]12[C@@H](O)CCN1C[C@H](O)[C@@H](O)[C@@H]2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Castanospermine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.46	50
	water	18.92	100

Preparing Stock Solutions for Castanospermine

The following data is based on the product molecular weight 189.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.29 mL	26.43 mL	52.85 mL
5 mM	1.06 mL	5.29 mL	10.57 mL
10 mM	0.53 mL	2.64 mL	5.29 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

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Reconstitution Calculator

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References for Castanospermine

References are publications that support the biological activity of the product.

Gruters Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 1987 PMID: 2959866
Welker Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 1987 PMID: 2825177
Saul Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 1984 PMID: 6424575

Citations for Castanospermine (1)

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Citations are publications that use Bio-Techne products. Selected citations for Castanospermine include:

Nacev et al. (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem. 286:44045
PMID: 22025615

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