Cannabinol

Name: Cannabinol
Brand: Tocris Bioscience
SKU: 3130

Tocris Bioscience a Bio-Techne Brand

Catalog # 3130

COA / SDS

Discontinued Product

3130 has been discontinued. View all Non-selective Cannabinoid Receptor Agonists products.

Key Product Details

Description:	Cannabinoid receptor agonist; not psychoactive
Alternative Names:	CBN
Chemical Name:	6,6,9-Trimethyl-3-pentyl-6H-benzo[c]chromen-1-ol
Molecular Weight:	310.43

View Full Technical Details for Cannabinol

Biological Activity for Cannabinol

Cannabinol is a CB₂ and CB₁ receptor agonist (K_i values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC₅₀ values are 120 and 261 nM for CB₁ and CB₂ receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.

Technical Data for Cannabinol

M. Wt	310.43
Formula	C₂₁H₂₆O₂
Storage	Store at -20°C
CAS Number	521-35-7
PubChem ID	2543
InChi Key	VBGLYOIFKLUMQG-UHFFFAOYSA-N
Smiles	CC1=CC2=C(C(C)(C)OC3=C2C(O)=CC(CCCCC)=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cannabinol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.52	50
	ethanol	3.1	10

Preparing Stock Solutions for Cannabinol

The following data is based on the product molecular weight 310.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.44 mL	32.21 mL	64.43 mL
2.5 mM	1.29 mL	6.44 mL	12.89 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
25 mM	0.13 mL	0.64 mL	1.29 mL

Molarity Calculator

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Reconstitution Calculator

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References for Cannabinol

References are publications that support the biological activity of the product.

Zygmunt Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB₁ and CB₂ cannabinoid receptor-independent mechanism. J.Neurosci. 2002 PMID: 12040079
Herring Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem.Pharmacol. 1998 PMID: 9605425
Rhee Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. J.Med.Chem. 1997 PMID: 9379442

Citations for Cannabinol

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