Buspirone hydrochloride

Name: Buspirone hydrochloride
Brand: Tocris Bioscience
SKU: 0962

Tocris Bioscience a Bio-Techne Brand

Catalog # 0962

Citations (4)

COA / SDS

Discontinued Product

0962 has been discontinued. View all 5-HT1 Receptor Agonists products.

Key Product Details

Description:	5-HT_1A partial agonist
Chemical Name:	8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	421.97

View Full Technical Details for Buspirone hydrochloride

Biological Activity for Buspirone hydrochloride

Buspirone hydrochloride is a classic 5-HT_1A partial agonist with relatively high affinity (K_i = 9.3 - 29.5 nM). A clinically effective anxiolytic.

Technical Data for Buspirone hydrochloride

M. Wt	421.97
Formula	C₂₁H₃₁N₅O₂.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	33386-08-2
PubChem ID	36431
InChi Key	RICLFGYGYQXUFH-UHFFFAOYSA-N
Smiles	Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Buspirone hydrochloride

References are publications that support the biological activity of the product.

Gobert Buspirone modulates basal and fluoxetine-stimulated dialysate levels of DA, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie i Neuroscience 1999 PMID: 10501449
Cao and Rodgers Comparative behavioural profiles of busp. and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology 1997 PMID: 9294974
Goa and Ward Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 1986 PMID: 2874976

Citations for Buspirone hydrochloride (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Buspirone hydrochloride include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 175
PMID: 32088264
Gutierrez et al. (2019) Endothelin neurotransmitter signalling controls zebrafish social behaviour. Sci Rep. 9:3040
PMID: 30816294
Norton and Gutiérrez (2019) The three-spined stickleback as a model for behavioural neuroscience. PLoS One. 14:e0213320
PMID: 30913214
Garavaglia et al. (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 11:7
PMID: 20085655

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Showing 1 - 4 of 4 citations Showing All

Product Documents for Buspirone hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.