Bazedoxifene acetate

Name: Bazedoxifene acetate
Brand: Tocris Bioscience
SKU: 5263

Tocris Bioscience a Bio-Techne Brand

Catalog # 5263

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Key Product Details

Description:	Potent and selective estrogen receptor modulator (SERM)
Chemical Name:	1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate
Purity:	≥98% (HPLC)
Molecular Weight:	530.65

View Full Technical Details for Bazedoxifene acetate

Biological Activity for Bazedoxifene acetate

Bazedoxifene acetate is a potent selective estrogen receptor modulator (SERM) (IC₅₀ values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat. No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Bazedoxifene acetate

Bazedoxifene acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bazedoxifene acetate

M. Wt	530.65
Formula	C₃₀H₃₄N₂O₃.C₂H₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	198481-33-3
PubChem ID	154256
InChi Key	OMZAMQFQZMUNTP-UHFFFAOYSA-N
Smiles	CC2=C(C3=CC=C(O)C=C3)N(CC4=CC=C(OCCN5CCCCCC5)C=C4)C1=CC=C(O)C=C12.OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bazedoxifene acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	53.06	100
	ethanol	10.61	20

Preparing Stock Solutions for Bazedoxifene acetate

The following data is based on the product molecular weight 530.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.42 mL	18.84 mL
5 mM	0.38 mL	1.88 mL	3.77 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for Bazedoxifene acetate

References are publications that support the biological activity of the product.

Komm Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 2005 PMID: 15961563

Citations for Bazedoxifene acetate

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