Beta-Alanine as a ligand of glycine receptors
Glycine receptors of Alpha1+Beta subunit composition were expressed in HEK cells and then tested for functionality by beta-alanine application. As predicted, beta-alanine (1 mM) evoked a clear response, then fully blocked by strychnine (1 microM). Figure: response evoked by beta-alanine in a HEK-293 cell expressing glycine receptors.
Easily soluble compound, stable in water solution. Can be stored in fridge for months.