Arcyriaflavin A

Name: Arcyriaflavin A
Brand: tocris
SKU: 2457
Rating: 5 (1 reviews)

Catalog # 2457

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Key Product Details

Description:	Potent cdk4 inhibitor; also potently inhibits CaM kinase II; antiviral
Chemical Name:	12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	325.32

View Full Technical Details for Arcyriaflavin A

Biological Activity

Arcyriaflavin A is a potent cyclin-dependent kinase 4 (cdk4) inhibitor (IC₅₀ value reported between 60 and 190 nM). Displays activity at other cdks in the sub-micromolar range. Also potently inhibits CaM kinase II (IC₅₀ = 25 nM). Inhibits human cytomegalovirus (HCMV) replication in vitro.

Compound Libraries

Arcyriaflavin A is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	325.32
Formula	C₂₀H₁₁N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	118458-54-1
PubChem ID	5327723
InChi Key	KAJXOWFGKYKMMZ-UHFFFAOYSA-N
Smiles	O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.53	100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.37 mL	30.74 mL
5 mM	0.61 mL	3.07 mL	6.15 mL
10 mM	0.31 mL	1.54 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References

References are publications that support the biological activity of the product.

Slater Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 1999 PMID: 10428375
Zhu Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 2003 PMID: 12657252
Sanchez-Martinez Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 2003 PMID: 14552791
Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987

Citations

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Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs

Name: Anonymous

Species: Human

Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs as assessed using the 5-bromo-2-deoxyuridine (BrdU) and methylthiazoletetrazolium bromide (MTT) assays, and vascular endothelial growth factor (VEGF) ELISA.

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