Arcaine sulfate

Name: Arcaine sulfate
Brand: tocris
SKU: 0389

Catalog # 0389

Datasheet / COA / SDS

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Key Product Details

Description:	Competitive NMDA antagonist
Chemical Name:	N,N'-1,4-Butanediylbisguanidine sulfate
Purity:	≥99% (HPLC)
Molecular Weight:	270.31

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Biological Activity

NO synthase inhibitor. An NMDA antagonist acting as a competitive inhibitor at the polyamine site.

Technical Data

M. Wt	270.31
Formula	C₆H₁₆N₆.H₂SO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	14923-17-2
PubChem ID	119020
InChi Key	RWTGFMPOODRXIM-UHFFFAOYSA-N
Smiles	O=[SH2]([O])O[O].NC(NCCCCNC(N)=N)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		25

Preparing Stock Solutions

The following data is based on the product molecular weight 270.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.80 mL	73.99 mL	147.98 mL
1.25 mM	2.96 mL	14.80 mL	29.60 mL
2.5 mM	1.48 mL	7.40 mL	14.80 mL
12.5 mM	0.30 mL	1.48 mL	2.96 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Doyle and Shaw Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 1998 PMID: 9641557
Reynolds Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. Eur.J.Pharmacol. 1990 PMID: 2155812
Yokoi Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain. Neuropharmacology 1994 PMID: 7532812