AMI-193

Name: AMI-193
Brand: tocris
SKU: 0524

Catalog # 0524

Datasheet / COA / SDS

Discontinued Product

0524 has been discontinued. View all Non-selective Dopamine Receptor Antagonists products.

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	D₂-like antagonist; also selective 5-HT₂ antagonist
Alternative Names:	Spiramide
Chemical Name:	8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
Purity:	≥99% (HPLC)
Molecular Weight:	383.46

View Full Technical Details for AMI-193

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Biological Activity

AMI-193 is a selective 5-HT antagonist, which binds to 5-HT₂ sites as potently as spiperone but has lower affinity for 5-HT_2C receptors. Also a high affinity D₂ receptor antagonist (K_i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

Technical Data

M. Wt	383.46
Formula	C₂₂H₂₆FN₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	510-74-7
PubChem ID	68186
InChi Key	FJUKDAZEABGEIH-UHFFFAOYSA-N
Smiles	FC(C=C4)=CC=C4OCCCN1CCC2(N(C3=CC=CC=C3)CNC2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.76	75

Preparing Stock Solutions

The following data is based on the product molecular weight 383.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.48 mL	17.39 mL	34.77 mL
3.75 mM	0.70 mL	3.48 mL	6.95 mL
7.5 mM	0.35 mL	1.74 mL	3.48 mL
37.5 mM	0.07 mL	0.35 mL	0.70 mL

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References

References are publications that support the biological activity of the product.

Czoty Behavioural effects of AMI-193, a 5-HT_2A- and DA D₂-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 2000 PMID: 11124389
Ismaiel Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT₂ versus 5HT_1C selective antagonist. J.Med.Chem. 1993 PMID: 8355253