AMI-193

Name: AMI-193
Brand: Tocris Bioscience
SKU: 0524

Tocris Bioscience a Bio-Techne Brand

Catalog # 0524

COA / SDS

Discontinued Product

0524 has been discontinued. View all Non-selective Dopamine Receptor Antagonists products.

Key Product Details

Description:	D₂-like antagonist; also selective 5-HT₂ antagonist
Alternative Names:	Spiramide
Chemical Name:	8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
Purity:	≥99% (HPLC)
Molecular Weight:	383.46

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Biological Activity for AMI-193

AMI-193 is a selective 5-HT antagonist, which binds to 5-HT₂ sites as potently as spiperone but has lower affinity for 5-HT_2C receptors. Also a high affinity D₂ receptor antagonist (K_i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

Technical Data for AMI-193

M. Wt	383.46
Formula	C₂₂H₂₆FN₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	510-74-7
PubChem ID	68186
InChi Key	FJUKDAZEABGEIH-UHFFFAOYSA-N
Smiles	FC(C=C4)=CC=C4OCCCN1CCC2(N(C3=CC=CC=C3)CNC2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMI-193

Solubility

Soluble Soluble to 75 mM in DMSO

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References for AMI-193

References are publications that support the biological activity of the product.

Czoty Behavioural effects of AMI-193, a 5-HT_2A- and DA D₂-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 2000 PMID: 11124389
Ismaiel Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT₂ versus 5HT_1C selective antagonist. J.Med.Chem. 1993 PMID: 8355253

Citations for AMI-193

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AMI-193

Tocris Bioscience a Bio-Techne Brand

Key Product Details

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Biological Activity for AMI-193

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References for AMI-193

Citations for AMI-193

Product Documents for AMI-193

COA

Certificate of Analysis

SDS

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