Alrestatin

Name: Alrestatin
Brand: Tocris Bioscience
SKU: 0485

Tocris Bioscience a Bio-Techne Brand

Catalog # 0485

Citations (3)

COA / SDS

Discontinued Product

0485 has been discontinued. View all Aldose Reductase Inhibitors products.

Key Product Details

Description:	Aldose reductase inhibitor
Chemical Name:	1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid
Molecular Weight:	255.23

View Full Technical Details for Alrestatin

Biological Activity for Alrestatin

Alrestatin is a specific inhibitor of aldose reductase (IC₅₀ = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.

Technical Data for Alrestatin

M. Wt	255.23
Formula	C₁₄H₉NO₄
Storage	Store at RT
CAS Number	51411-04-2
PubChem ID	2120
InChi Key	GCUCIFQCGJIRNT-UHFFFAOYSA-N
Smiles	OC(=O)CN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Alrestatin

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Alrestatin

References are publications that support the biological activity of the product.

Lavrentyev Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 2007 PMID: 17626897
Barski The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 1996 PMID: 8916913
Ehrig Mechanism of aldose reductase inhibition: binding of NADP⁺/NADPH and alrestatin-like inhibitors. Biochemistry 1994 PMID: 8003482

Citations for Alrestatin (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Alrestatin include:

Mochin et al. (2015) Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. PLoS One. 97:55
PMID: 25283348
Bresson et al. (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol. 3:98
PMID: 22654757
Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol. 296:H106
PMID: 18978194

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