AH 6809

Tocris Bioscience a Bio-Techne Brand

Catalog # 0671

Citations (6)

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Key Product Details

Description:	EP₁ and EP₂ receptor antagonist
Chemical Name:	6-Isopropoxy-9-xanthone-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	298.3

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Biological Activity for AH 6809

AH 6809 is an antagonist at prostaglandin EP₁ (pA₂ = 6.8) and EP₂ (K_i = 350 nM) receptors. Also weakly inhibits DP receptors (pA₂ = 4.45).

Compound Libraries for AH 6809

AH 6809 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AH 6809

M. Wt	298.3
Formula	C₁₇H₁₄O₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	33458-93-4
PubChem ID	119461
InChi Key	AQFFXPQJLZFABJ-UHFFFAOYSA-N
Smiles	CC(C)OC1=CC=C2C(OC3=C(C=C(C=C3)C(O)=O)C2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AH 6809

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1.1eq. NaOH	29.83	100
	DMSO	29.83	100

Preparing Stock Solutions for AH 6809

The following data is based on the product molecular weight 298.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for AH 6809

References are publications that support the biological activity of the product.

van der Merwe Prostaglandin E₂ derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. J.Pharmacol.Exp.Ther. 2009 PMID: 19190238
Kiriyama Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 1997 PMID: 9313928
Keery and Lumley AH 6809, a prostaglandin DP-receptor blocking drug on human platelets. Br.J.Pharmacol. 1988 PMID: 2460179
Coleman AH6809, a prostanoid EP₁-receptor blocking drug. Br.J.Pharmacol.

Citations for AH 6809 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for AH 6809 include:

Liu et al. (2016) Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice PLoS One. 11:e0165200
PMID: 27812120
Jansen et al. (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Dent Res J (Isfahan). 19:210
PMID: 25266063
Chia et al. (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 11:10
PMID: 21955547
Passafaro et al. (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Br J Pharmacol. 8:138
PMID: 22013477
Schaafsma et al. (2007) Ins induces airway smooth muscle contraction. J Pharmacol Exp Ther. 150:136
PMID: 17160007
Walsh and Kinsella (2000) Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol. 131:601
PMID: 11015313

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Showing 1 - 6 of 6 citations Showing All

Product Documents for AH 6809

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.