AH 11110 hydrochloride

Name: AH 11110 hydrochloride
Brand: Tocris Bioscience
SKU: 0998

Catalog # 0998

COA / SDS

Discontinued Product

0998 has been discontinued. View all Adrenergic alpha-1 Receptor Ligands products.

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	Subtype-selective α_1B ligand
Chemical Name:	4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	374.91

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Biological Activity

AH 11110 hydrochloride is a subtype-selective ligand for the α_1B-adrenoceptor. The pK_i values for binding to rat fibroblast cell membranes expressing α_1B (hamster), α_1A (bovine) and α_1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α₁ subtypes and α₂ receptors in smooth muscle preparations.

Technical Data

M. Wt	374.91
Formula	C₂₁H₂₆N₂O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	179388-65-9
PubChem ID	9907616
InChi Key	WWHGFIXWBLHHQB-UHFFFAOYSA-N
Smiles	Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		25

Preparing Stock Solutions

The following data is based on the product molecular weight 374.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.67 mL	53.35 mL	106.69 mL
1.25 mM	2.13 mL	10.67 mL	21.34 mL
2.5 mM	1.07 mL	5.33 mL	10.67 mL
12.5 mM	0.21 mL	1.07 mL	2.13 mL

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References

References are publications that support the biological activity of the product.

Eltze Failure of AH11110A to functionally discriminate between α₁-adrenoceptor subtypes A, B and D or between α₁- and α₂-adrenoceptors. Eur.J.Pharmacol. 2001 PMID: 11275009
Saussy Structure-activity relationships of a series of busp. analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 1996 PMID: 8764344
King AH 11110A is selective for the α_1B-subtype of α₁-adrenoceptors. Soc.Neurosci.Abstr.

Citations for AH 11110 hydrochloride

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