AH 11110 hydrochloride

Name: AH 11110 hydrochloride
Brand: Tocris Bioscience
SKU: 0998

Tocris Bioscience a Bio-Techne Brand

Catalog # 0998

COA / SDS

Discontinued Product

0998 has been discontinued. View all Adrenergic alpha-1 Receptor Ligands products.

Key Product Details

Description:	Subtype-selective α_1B ligand
Chemical Name:	4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	374.91

View Full Technical Details for AH 11110 hydrochloride

Complete Your Research

Biological Activity for AH 11110 hydrochloride

AH 11110 hydrochloride is a subtype-selective ligand for the α_1B-adrenoceptor. The pK_i values for binding to rat fibroblast cell membranes expressing α_1B (hamster), α_1A (bovine) and α_1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α₁ subtypes and α₂ receptors in smooth muscle preparations.

Technical Data for AH 11110 hydrochloride

M. Wt	374.91
Formula	C₂₁H₂₆N₂O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	179388-65-9
PubChem ID	9907616
InChi Key	WWHGFIXWBLHHQB-UHFFFAOYSA-N
Smiles	Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AH 11110 hydrochloride

Solubility

Soluble Soluble to 25 mM in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AH 11110 hydrochloride

References are publications that support the biological activity of the product.

Eltze Failure of AH11110A to functionally discriminate between α₁-adrenoceptor subtypes A, B and D or between α₁- and α₂-adrenoceptors. Eur.J.Pharmacol. 2001 PMID: 11275009
Saussy Structure-activity relationships of a series of busp. analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 1996 PMID: 8764344
King AH 11110A is selective for the α_1B-subtype of α₁-adrenoceptors. Soc.Neurosci.Abstr.

Citations for AH 11110 hydrochloride

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.