AG 556

Catalog # 0616

Datasheet / COA / SDS

Discontinued Product

0616 has been discontinued. View all EGF Receptor Inhibitors products.

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	EGFR-kinase inhibitor
Alternative Names:	Tyrphostin AG 556
Chemical Name:	(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Purity:	≥99% (HPLC)
Molecular Weight:	336.39

View Full Technical Details for AG 556

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 1.1 μM). Selective over ErbB2 (IC₅₀ > 500 μM).

Technical Data

M. Wt	336.39
Formula	C₂₀H₂₀N₂O₃
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	133550-41-1
PubChem ID	5328775
InChi Key	GWCNJMUSWLTSCW-SFQUDFHCSA-N
Smiles	OC1=C(O)C=C(\C=C(/C#N)C(=O)NCCCCC2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.09	30

Preparing Stock Solutions

The following data is based on the product molecular weight 336.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	9.91 mL	49.55 mL	99.09 mL
1.5 mM	1.98 mL	9.91 mL	19.82 mL
3 mM	0.99 mL	4.95 mL	9.91 mL
15 mM	0.20 mL	0.99 mL	1.98 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Gamett Secondary dimerization between members of the epidermal growth factor receptor family. J.Biol.Chem. 1997 PMID: 9115272
Gazit Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 1991 PMID: 1676428