AG 555

Tocris Bioscience a Bio-Techne Brand

Catalog # 0618

COA / SDS

Discontinued Product

0618 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description:	Potent EGFR-kinase inhibitor
Alternative Names:	Tyrphostin AG 555
Chemical Name:	(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide
Purity:	≥99% (HPLC)
Molecular Weight:	322.36

View Full Technical Details for AG 555

Biological Activity for AG 555

AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G₁ growth arrest selectively in transformed cells (IC₅₀ values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).

Technical Data for AG 555

M. Wt	322.36
Formula	C₁₉H₁₈N₂O₃
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	133550-34-2
PubChem ID	5328770
InChi Key	GSQOBTOAOGXIFL-LFIBNONCSA-N
Smiles	OC1=CC=C(\C=C(/C#N)C(=O)NCCCC2=CC=CC=C2)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AG 555

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.67	30

Preparing Stock Solutions for AG 555

The following data is based on the product molecular weight 322.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	10.34 mL	51.70 mL	103.40 mL
1.5 mM	2.07 mL	10.34 mL	20.68 mL
3 mM	1.03 mL	5.17 mL	10.34 mL
15 mM	0.21 mL	1.03 mL	2.07 mL

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References for AG 555

References are publications that support the biological activity of the product.

Ben-Bassat Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 1999 PMID: 10454524
Levitzki and Gazit Tyrosine kinase inhibition: an approach to drug development. Science 1995 PMID: 7892601
Gazit Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 1991 PMID: 1676428

Citations for AG 555

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AG 555

Tocris Bioscience a Bio-Techne Brand

Key Product Details

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Biological Activity for AG 555

Technical Data for AG 555

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Preparing Stock Solutions for AG 555

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for AG 555

Citations for AG 555

Product Documents for AG 555

COA

Certificate of Analysis

SDS

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