Acyclovir

Name: Acyclovir
Brand: Tocris Bioscience
SKU: 2513
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 2513

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Key Product Details

Description:	Inhibits viral DNA polymerase; antiherpetic agent
Alternative Names:	Aciclovir, Acycloguanosine
Chemical Name:	2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Purity:	≥99% (HPLC)
Molecular Weight:	225.21

View Full Technical Details for Acyclovir

Biological Activity for Acyclovir

Acyclovir is an antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC₅₀ values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Compound Libraries for Acyclovir

Acyclovir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Acyclovir

M. Wt	225.21
Formula	C₈H₁₁N₅O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	59277-89-3
PubChem ID	2022
InChi Key	MKUXAQIIEYXACX-UHFFFAOYSA-N
Smiles	NC1=NC(=O)C2=C(N1)N(COCCO)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Acyclovir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	11.26	50
	DMSO	4.5	20

Preparing Stock Solutions for Acyclovir

The following data is based on the product molecular weight 225.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.88 mL	44.40 mL	88.81 mL
2.5 mM	1.78 mL	8.88 mL	17.76 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
25 mM	0.18 mL	0.89 mL	1.78 mL

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Reconstitution Calculator

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References for Acyclovir

References are publications that support the biological activity of the product.

Hayashi The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 2006 PMID: 16779868
Suzuki Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 PMID: 16797734
Elion Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA.

Citations for Acyclovir

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Acyclovir was studied in conjunction with few contemporary chemotherapy strategies

Name: Anonymous

Species: Human

Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.

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