ACBC

Catalog # 0258

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	NMDA antagonist; acts at glycine site
Chemical Name:	1-Aminocyclobutane-1-carboxylic acid
Molecular Weight:	115.13

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Biological Activity

NMDA receptor partial agonist, acting at the glycine site of GluN1 (formally NR1).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M. Wt	115.13
Formula	C₅H₉NO₂
Storage	Store at RT
CAS Number	22264-50-2
PubChem ID	89643
InChi Key	FVTVMQPGKVHSEY-UHFFFAOYSA-N
Smiles	NC1(CCC1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 115.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.69 mL	43.43 mL	86.86 mL
5 mM	1.74 mL	8.69 mL	17.37 mL
10 mM	0.87 mL	4.34 mL	8.69 mL
50 mM	0.17 mL	0.87 mL	1.74 mL

Molarity Calculator

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Hood 1-Aminocyclobutane-1-carboxylic acid (ACBC): a specific antagonist of the NMDA receptor coupled glycine receptor. Eur.J.Pharmacol. 1989 PMID: 2542048
Inanobe Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron 2005 PMID: 15996549
Rao Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-MthD.-aspartate-associated glycine receptor. Neuropharmacology 1990 PMID: 2158004