α-Conotoxin AuIB

Name: α -Conotoxin AuIB
Brand: Tocris Bioscience
SKU: 3120
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3120

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Key Product Details

Description:	Selective α3β4 nAChR antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1572.76

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Biological Activity for α-Conotoxin AuIB

α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.

Licensing Information

Sold under license from University of Utah

Technical Data for α-Conotoxin AuIB

M. Wt	1572.76
Formula	C₆₅H₈₉N₁₇O₂₁S₄
Single Letter Sequence	GCCSYPPCFATNPDC (Modifications: Cys-15 = C-terminal amide, Disulfide bridges: 2-8, 3-15)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	216299-21-7
PubChem ID	73755065
InChi Key	SVNSCQIKKAACJG-SBLJLSJOSA-N
Smiles	C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N3)NC(=O)CN)C(=O)N[C@H](C(=O)N1)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)CO)C(=O)N)CC(=O)O)CC(=O)N)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Conotoxin AuIB

Solubility

Soluble to 5mg/ml in water

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References for α-Conotoxin AuIB

References are publications that support the biological activity of the product.

Park An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons. Pflugers Arch. 2006 PMID: 16715294
Nai Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol.Pharmacol. 2003 PMID: 12527802
Luo α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked NE release. J.Neurosci. 1998 PMID: 9786965

Citations for α-Conotoxin AuIB

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Customer Reviews for α-Conotoxin AuIB (1)

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Gold standard to compare analgesic drugs

Name: Luiz Alexandre Magno

Species: Rat

Assay Type: In Vivo

In our lab we used this product as a gold standard to compare analgesic effects of different toxins. It works very well in rodents.

Intrathecal administration works great

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Product Documents for α-Conotoxin AuIB

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.