8-M-PDOT

Name: 8-M-PDOT
Brand: Tocris Bioscience
SKU: 1035

Tocris Bioscience a Bio-Techne Brand

Catalog # 1035

COA / SDS

Discontinued Product

1035 has been discontinued. View all Melatonin (MT) Receptor Agonists products.

Key Product Details

Description:	Melatonin agonist
Chemical Name:	8-Methoxy-2-propionamidotetralin
Purity:	≥99% (HPLC)
Molecular Weight:	233.31

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Biological Activity for 8-M-PDOT

8-M-PDOT is a melatonin receptor agonist, 20-fold selective for the MT₂ (vs MT₁) subtype. At human recombinant MT₁ and MT₂ receptors, displays pK_i values of 8.23 and 8.95 respectively.

Technical Data for 8-M-PDOT

M. Wt	233.31
Formula	C₁₄H₁₉NO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	134865-70-6
PubChem ID	5170952
InChi Key	RVIGBTUDFAGRTQ-UHFFFAOYSA-N
Smiles	CCC(=O)NC1CCC2=C(C1)C(OC)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 8-M-PDOT

	Solvent	Max Conc. mM
Solubility
	ethanol	50
	DMSO	100

Preparing Stock Solutions for 8-M-PDOT

The following data is based on the product molecular weight 233.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.29 mL	21.43 mL	42.86 mL
5 mM	0.86 mL	4.29 mL	8.57 mL
10 mM	0.43 mL	2.14 mL	4.29 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

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References for 8-M-PDOT

References are publications that support the biological activity of the product.

Browning Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 2000 PMID: 10696085
Dubocovich Melatonin receptor antagonists that differentiate between the human Mel_1a and Mel_1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML₁ presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089668
Dubocovich Melatonin receptors: are there multiple subtypes? TiPS 1995 PMID: 7762083

Citations for 8-M-PDOT

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