4BP-TQS

Name: 4BP-TQS
Brand: Tocris Bioscience
SKU: 4234

Tocris Bioscience a Bio-Techne Brand

Catalog # 4234

Citations (1)

COA / SDS

Discontinued Product

4234 has been discontinued. View all Nicotinic (a7) Receptor Agonists products.

Key Product Details

Description:	α7 nAChR agonist; acts at an allosteric site
Chemical Name:	4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	405.31

View Full Technical Details for 4BP-TQS

Biological Activity for 4BP-TQS

4BP-TQS is an allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC₅₀ value and 45-fold larger maximal response.

Technical Data for 4BP-TQS

M. Wt	405.31
Formula	C₁₈H₁₇BrN₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	360791-49-7
PubChem ID	2857838
InChi Key	YNCXHXYZTLIZTO-UHFFFAOYSA-N
Smiles	BrC1=CC=C(C2NC(C=CC(S(=O)(N)=O)=C4)=C4C3C2CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4BP-TQS

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.53	100

Preparing Stock Solutions for 4BP-TQS

The following data is based on the product molecular weight 405.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.34 mL	24.67 mL
5 mM	0.49 mL	2.47 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for 4BP-TQS

References are publications that support the biological activity of the product.

Gill Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 21436053

Citations for 4BP-TQS (1)

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Citations are publications that use Bio-Techne products. Selected citations for 4BP-TQS include:

Zhang et al. (2015) Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. Proc Natl Acad Sci U S A. 10:e0137588
PMID: 26340537

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Product Documents for 4BP-TQS

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.