4-IBP

Name: 4-IBP
Brand: Tocris Bioscience
SKU: 0748

Tocris Bioscience a Bio-Techne Brand

Catalog # 0748

Citations (2)

COA / SDS

Discontinued Product

0748 has been discontinued. View all Sigma1 Receptor Ligands products.

Key Product Details

Description:	σ ligand, σ₁> σ₂
Chemical Name:	N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	420.29

View Full Technical Details for 4-IBP

Biological Activity for 4-IBP

Combines high affinity for σ₁ and moderate affinity for σ₂ sites. Centrally active following systemic administration in vivo.

Technical Data for 4-IBP

M. Wt	420.29
Formula	C₁₉H₂₁IN₂O
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	155798-08-6
PubChem ID	132995
InChi Key	HELCSESNNDZLFM-UHFFFAOYSA-N
Smiles	IC1=CC=C(C=C1)C(=O)NC1CCN(CC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-IBP

	Solvent	Max Conc. mM
Solubility
	DMSO	10
	ethanol	5

Preparing Stock Solutions for 4-IBP

The following data is based on the product molecular weight 420.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.79 mL	118.97 mL	237.93 mL
0.5 mM	4.76 mL	23.79 mL	47.59 mL
1 mM	2.38 mL	11.90 mL	23.79 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 4-IBP

References are publications that support the biological activity of the product.

Bermack and Debonnel Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 2001 PMID: 11588125
Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571
John Synthesis and characterisation of [¹²⁵I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 1994 PMID: 8021913

Citations for 4-IBP (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for 4-IBP include:

Rodríguez-Muñoz et al. (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 11:51
PMID: 30223868
Amer et al. (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 168:1445
PMID: 23121507

There are no citations that match your criteria.