4-IBP

Name: 4-IBP
Brand: tocris
SKU: 0748

Catalog # 0748

Citations (2)

Datasheet / COA / SDS

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Key Product Details

Description:	σ ligand, σ₁> σ₂
Chemical Name:	N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	420.29

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Biological Activity

Combines high affinity for σ₁ and moderate affinity for σ₂ sites. Centrally active following systemic administration in vivo.

Technical Data

M. Wt	420.29
Formula	C₁₉H₂₁IN₂O
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	155798-08-6
PubChem ID	132995
InChi Key	HELCSESNNDZLFM-UHFFFAOYSA-N
Smiles	IC1=CC=C(C=C1)C(=O)NC1CCN(CC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	10
	ethanol	5

Preparing Stock Solutions

The following data is based on the product molecular weight 420.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.79 mL	118.97 mL	237.93 mL
0.5 mM	4.76 mL	23.79 mL	47.59 mL
1 mM	2.38 mL	11.90 mL	23.79 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

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References

References are publications that support the biological activity of the product.

Bermack and Debonnel Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 2001 PMID: 11588125
John Synthesis and characterisation of [¹²⁵I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 1994 PMID: 8021913
Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for 4-IBP include:

Rodríguez-Muñoz et al. (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 11:51
PMID: 30223868
Amer et al. (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 168:1445
PMID: 23121507

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Product Datasheets

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Certificate of Analysis

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4-IBP

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Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (2)

Product Datasheets

COA

Certificate of Analysis

SDS

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