3'-Fluorobenzylspiperone maleate

Name: 3'-Fluorobenzylspiperone maleate
Brand: tocris
SKU: 0701

Catalog # 0701

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	D₂-like receptor ligand
Chemical Name:	8-[4-(4-Fluorophenyl)-4-oxobutyl]-(3-fluorobenzyl-1-phenyl)-1,3,8-triazaspiro[4,5]decan-4-one maleate
Purity:	≥98% (HPLC)
Molecular Weight:	619.67

View Full Technical Details for 3'-Fluorobenzylspiperone maleate

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Biological Activity

A very potent and selective ligand for the D₂ receptor (K_i = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D₂ and a 12-fold lower affinity at 5-HT₂ receptors.

Technical Data

M. Wt	619.67
Formula	C₃₀H₃₁F₂N₃O₂.C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1135278-61-3
PubChem ID	24978532
InChi Key	JURUFADWVGXLOY-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CN(CC1=CC=CC(F)=C1)C2=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	15.49	25

Preparing Stock Solutions

The following data is based on the product molecular weight 619.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.46 mL	32.28 mL	64.55 mL
1.25 mM	1.29 mL	6.46 mL	12.91 mL
2.5 mM	0.65 mL	3.23 mL	6.46 mL
12.5 mM	0.13 mL	0.65 mL	1.29 mL

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References

References are publications that support the biological activity of the product.

Mach Effect of N-alkylation on the affinities of analogues of spiperone for DA D₂ and serotonin 5-HT₂ receptors. J.Med.Chem. 1992 PMID: 1531364