2-PMDQ

Catalog # 0627

Datasheet / COA / SDS

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Key Product Details

Description:	Potent, selective α₁ antagonist
Chemical Name:	2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one

View Full Technical Details for 2-PMDQ

Biological Activity

Potent and selective α₁-adrenoceptor antagonist and antihypertensive.

Technical Data

M. Wt	361.45
Formula	C₂₁H₂₃N₅O
Storage	Store at RT
CAS Number	139047-55-5
PubChem ID	6081682
InChi Key	ONSOQRPYFKDOEB-UHFFFAOYSA-N
Smiles	O=C1NC2=C(C=CC=C2)C2=NC(CN3CCN(CC3)C3=CC=CC=C3)CN12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.61	10
	ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 361.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.67 mL	138.33 mL	276.66 mL
0.5 mM	5.53 mL	27.67 mL	55.33 mL
1 mM	2.77 mL	13.83 mL	27.67 mL
5 mM	0.55 mL	2.77 mL	5.53 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Chern Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives - a novel class of potent and selective α₁-adrenoceptor antagonists and antihypertensive agents. J.Med.Chem. 1993 PMID: 8101878

Citations

Currently there are no citations for 2-PMDQ.

Product Datasheets

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.