2-CMDO

Name: 2-CMDO
Brand: tocris
SKU: 0782

Catalog # 0782

Datasheet / COA / SDS

Discontinued Product

0782 has been discontinued. View all Non-selective Dopamine Receptor Antagonists products.

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	D₂-like antagonist; displays some D₄ selectivity
Chemical Name:	2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate
Molecular Weight:	442.9

View Full Technical Details for 2-CMDO

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Biological Activity

2-CMDO is a dopamine D₂-like receptor antagonist that displays some selectivity for D₄ receptors (K_i values are 0.54 and 2.5 nM for D₄ and D₂ receptors respectively).

Technical Data

M. Wt	442.9
Formula	C₁₉H₁₉ClN₂O.C₄H₄O₄
Storage	Store at RT
CAS Number	24140-98-5
PubChem ID	71296946
InChi Key	OOHVXDUNWCMZCI-WLHGVMLRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CN1CCN(CC1)C1=CC2=C(OC3=C1C=C(Cl)C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.29	100

Preparing Stock Solutions

The following data is based on the product molecular weight 442.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Phillips Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 1994 PMID: 8064797
Phillips Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 1995 PMID: 7861418
Zawilska L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D₄-DA receptors. J.Neural Transm. 2003 PMID: 12658371