2-CMDO

Name: 2-CMDO
Brand: tocris
SKU: 0782

Catalog # 0782

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	D₂-like antagonist; displays some D₄ selectivity
Chemical Name:	2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate

View Full Technical Details for 2-CMDO

Biological Activity

Dopamine D₂-like receptor antagonist that displays some selectivity for D₄ receptors (K_i values are 0.54 and 2.5 nM for D₄ and D₂ receptors respectively).

Technical Data

M. Wt	442.9
Formula	C₁₉H₁₉ClN₂O.C₄H₄O₄
Storage	Store at RT
CAS Number	24140-98-5
PubChem ID	71296946
InChi Key	OOHVXDUNWCMZCI-WLHGVMLRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CN1CCN(CC1)C1=CC2=C(OC3=C1C=C(Cl)C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.29	100

Preparing Stock Solutions

The following data is based on the product molecular weight 442.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Phillips Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 1994 PMID: 8064797
Phillips Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 1995 PMID: 7861418
Zawilska L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D₄-DA receptors. J.Neural Transm. 2003 PMID: 12658371