2-CMDO

Name: 2-CMDO
Brand: Tocris Bioscience
SKU: 0782

Tocris Bioscience a Bio-Techne Brand

Catalog # 0782

COA / SDS

Discontinued Product

0782 has been discontinued. View all Non-selective Dopamine Receptor Antagonists products.

Key Product Details

Description:	D₂-like antagonist; displays some D₄ selectivity
Chemical Name:	2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate
Molecular Weight:	442.9

View Full Technical Details for 2-CMDO

Complete Your Research

Biological Activity for 2-CMDO

2-CMDO is a dopamine D₂-like receptor antagonist that displays some selectivity for D₄ receptors (K_i values are 0.54 and 2.5 nM for D₄ and D₂ receptors respectively).

Technical Data for 2-CMDO

M. Wt	442.9
Formula	C₁₉H₁₉ClN₂O.C₄H₄O₄
Storage	Store at RT
CAS Number	24140-98-5
PubChem ID	71296946
InChi Key	OOHVXDUNWCMZCI-WLHGVMLRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CN1CCN(CC1)C1=CC2=C(OC3=C1C=C(Cl)C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-CMDO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.29	100

Preparing Stock Solutions for 2-CMDO

The following data is based on the product molecular weight 442.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 2-CMDO

References are publications that support the biological activity of the product.

Zawilska L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D₄-DA receptors. J.Neural Transm. 2003 PMID: 12658371
Phillips Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 1995 PMID: 7861418
Phillips Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 1994 PMID: 8064797

Citations for 2-CMDO

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.