Voltage-gated Potassium Channel Modulators: Small Molecules and Peptides

Voltage-gated potassium channels (K_V) belong to the 6-TM family of potassium channel that also comprises the Ca²⁺-activated Slo (actually 7-TM) and the Ca²⁺-activated SK subfamilies. The pore-forming α-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. K_V1.1 with K_V1.2 and KCNQ2 with KCNQ3.